Document 0091
 DOCN  M9470091
 TI    Associations between HLA frequencies and pathogenic features of human
       immunodeficiency virus type 1 infection in seroconverters from the
       Amsterdam cohort of homosexual men.
 DT    9409
 AU    Klein MR; Keet IP; D'Amaro J; Bende RJ; Hekman A; Mesman B; Koot M; de
       Waal LP; Coutinho RA; Miedema F; Department of Clinical Viro-Immunology,
       Central Laboratory of The; Netherlands, Red Cross Blood Transfusion
       Service, Amsterdam.
 SO    J Infect Dis. 1994 Jun;169(6):1244-9. Unique Identifier : AIDSLINE
       MED/94253581
 AB    HLA-disease associations may be important for understanding the
       pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection.
       Therefore, 106 homosexual men from the Amsterdam Cohort Study on AIDS
       with a known date of HIV-1 seroconversion were serologically typed for
       HLA. Several significant associations between HLA type and pathogenic
       features of HIV-1 infection were observed: Subjects with fever and skin
       rash during primary HIV-1 infection showed an increased frequency of
       HLA-B62 (relative risk [RR], 5.8; P = .005). The frequency of HLA-B35
       was increased in subjects with a rapid decline in CD4+ T lymphocytes
       (RR, 3.2; P = .021). Kaplan-Meier survival analysis revealed a
       significant association between HLA-B35 and a decrease in CD4+ cells to
       < 200/microL (P = .01). The strongest association was found between
       HLA-DR1 and AIDS-related Kaposi's sarcoma (RR, 22.5; P < .001), also
       confirmed in survival analysis (P = .001). In AIDS patients with only
       opportunistic infections, increased frequencies of HLA-DR3 (P = .011)
       and -DQ2 (P = .007) were observed. Finally, the occurrence of
       syncytium-inducing HIV-1 variants was significantly associated with
       HLA-DQ2 (P = .01).
 DE    Cohort Studies  Follow-Up Studies  Homosexuality  Human  HIV
       Seropositivity/EPIDEMIOLOGY/*IMMUNOLOGY/*PHYSIOPATHOLOGY
       HIV-1/*IMMUNOLOGY  HLA Antigens/*ANALYSIS  Male
       Netherlands/EPIDEMIOLOGY  Phenotype  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

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